English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference[1], only 36 PEG polymers included)
سی بٱئرکنوݩ – سی ڤرداشتن، درتیچ کردن ۉ داٛین سی کار
د نۊ د یٱک شؽڤسن – سی هومدٱنڳی ڤا کار
زؽر نخیز شٱرتؽا هاری:
کاریاری کردن – شما بایٱد آرنڳ ناْ جۊرؽ کاْ ڤ دٱس نڤیسکاریا موجٱڤز دٱ موشٱخٱس بیٱ، نسبٱت کاری بٱکؽت(ڤلی نٱ جۊرؽ کاْ ڤانمۊد بۊئٱ کاْ ڤنو شما یا ڤ کار گرتن شما ناْ د آرنڳ پر ۉ پیم کاری کردنٱ).
https://creativecommons.org/licenses/by/4.0CC BY 4.0 Creative Commons Attribution 4.0 truetrue
↑ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews60 (1): 59-68. PMID17826865.